Dewleen Bakerx250
Contact Information:
3350 La Jolla Village Drive
San Diego, CA 92161
dgbaker@ucsd.edu

Biography

Dr. Baker earned her medical degree from Columbia University College of Physicians & Surgeons (1981), and completed adult and child psychiatry fellowships at the University of Cincinnati (UC) after which she joined the UC faculty as Assistant Professor of Child Psychiatry in 1986.  She began work at the Cincinnati VA in 1989, and over the next decade was responsible for developing the VA Cincinnati PTSD inpatient, residential and outpatient treatment programs and the Gulf War Illness Clinic.  She was recruited to the VA San Diego Healthcare System (VASDHS) in 2004.  Since arrival in San Diego her primary activities have been research, teaching and clinical work focused on PTSD, mTBI and co-occurring illnesses.  She was appointed to the Psychiatry faculty at University of California, San Diego San as Associate Professor in 2005.  She continues on faculty as Professor, Department of Psychiatry from 2012 to present.

Research/Clinical Interests

Dr. Baker’s main research foci have been the neurobiology of PTSD and mTBI, the interface between PTSD and mild traumatic brain injury (mTBI), and co-occurring disorders, such as cardiac, immune disorders and pain syndromes), seen at higher rates in PTSD and mTBI than in healthy individuals.  As outlined in her NIH biosketch her main areas of research contribution throughout her career include: 1) serial cerebrospinal fluid and plasma collection for circadian characterization of neuro-endocrine-immune peptides and hormones across the blood brain barrier in PTSD; 2) design and implementation of a large, prospective (pre- and post-deployment), longitudinal study of active duty Marines, the Marine Resiliency Study (MRS), which has contributed information about risk/resilience factor for development of PTSD; 3) in-depth inquiry into the participation of inflammation in the pathogenesis of PTSD, and the role of inflammation in secondary PTSD-related health-outcomes such as atherosclerotic heart disease; and 4) In tandem with Mingxiong Huang Ph.D., development of imaging biomarkers for the detection of mTBI as distinguished from PTSD; and 5) development of, and participation in single-site and multi-site studies of the safety and efficacy of new treatments (pharmaceutical compounds and neural stimulation) in the treatment of PTSD and mTBI.

At present, Dr. Baker is a teaching attending in the VA San Diego PTSD clinic (Mission Valley).  Additionally, throughout her career in Cincinnati and San Diego, she has served as mentor for numerous psychology undergraduate and graduate students, medical residents, fellows, post-doctoral fellows.  She also participates in delivery of lectures at UCSD and presents at conferences nationally and internationally.

To participate in current research studies, please visit VASDHS and  VMRF.

Selected Publications

  • Wolf EJ, Maniates H, Nugent N, Maihofer AX, Armstrong D, Ratanatharathorn A, Ashley-Koch AE, Garrett M, Kimbrel NA, Lori A, Va Mid-Atlantic Mirecc Workgroup, Aiello AE, Baker DG, Beckham JC, Boks MP, Galea S, Geuze E, Hauser MA, Kessler RC, Koenen KC, Miller MW, Ressler KJ, Risbrough V, Rutten BPF, Stein MB, Ursano RJ, Vermetten E, Vinkers CH, Uddin M, Smith AK, Nievergelt CM, Logue MW. (2017) Traumatic stress and accelerated DNA methylation age: A meta-analysis. Psychoneuroendocrinology. Dec 27. pii: S0306-4530(17)31260-X. doi:10.1016/j.psyneuen.2017.12.007. [Epub ahead of print]
  • Snijders C, de Nijs L, Baker DG, Hauger RL, van den Hove D, Kenis G, Nievergelt CM, Boks MP, Vermetten E, Gage FH, Rutten BPF. (2017) MicroRNAs in Post-traumatic Stress Disorder. Curr Top Behav Neurosci. Oct 21. doi:10.1007/7854_2017_32. [Epub ahead of print]
  • Ratanatharathorn A, Boks MP, Maihofer AX, Aiello AE, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Bromet E, Dennis M, Garrett ME, Geuze E, Guffanti G, Hauser MA, Kilaru V, Kimbrel NA, Koenen KC, Kuan PF, Logue MW, Luft BJ, Miller MW, Mitchell C, Nugent NR, Ressler KJ, Rutten BPF, Stein MB, Vermetten E, Vinkers CH, Youssef NA; VA Mid-Atlantic MIRECC Workgroup; PGC PTSD Epigenetics Workgroup, Uddin M, Nievergelt CM, Smith AK. (2017) Epigenome-wide association of PTSD from heterogeneous cohorts with a common multi-site analysis pipeline. Am J Med Genet B Neuropsychiatr Genet. 174(6):619-630.
  • Nolte IM, Munoz ML, Tragante V, Amare AT, Jansen R, Vaez A, von der Heyde B, Avery CL, Bis JC, Dierckx B, van Dongen J, Gogarten SM, Goyette P, Hernesniemi J, Huikari V, Hwang SJ, Jaju D, Kerr KF, Kluttig A, Krijthe BP, Kumar J, van der Laan SW, Lyytikäinen LP, Maihofer AX, Minassian A, van der Most PJ, Müller-Nurasyid M, Nivard M, Salvi E, Stewart JD, Thayer JF, Verweij N, Wong A, Zabaneh D, Zafarmand MH, Abdellaoui A, Albarwani S, Albert C, Alonso A, Ashar F,  Auvinen J, Axelsson T, Baker DG, de Bakker PIW, Barcella M, Bayoumi R, Bieringa RJ, Boomsma D, Boucher G, Britton AR, Christophersen I, Dietrich A, Ehret GB, Ellinor PT, Eskola M, Felix JF, Floras JS, Franco OH, Friberg P, Gademan MGJ, Geyer MA, Giedraitis V, Hartman CA, Hemerich D, Hofman A, Hottenga JJ, Huikuri H, Hutri-Kähönen N, Jouven X, Junttila J, Juonala M, Kiviniemi AM, Kors JA, Kumari M, Kuznetsova T, Laurie CC, Lefrandt JD, Li Y, Li Y, Liao D, Limacher MC, Lin HJ, Lindgren CM, Lubitz SA, Mahajan A, McKnight B, Zu Schwabedissen HM, Milaneschi Y, Mononen N, Morris AP, Nalls MA, Navis G, Neijts M, Nikus K, North KE, O’Connor DT, Ormel J, Perz S, Peters A, Psaty BM, Raitakari OT, Risbrough VB, Sinner MF, Siscovick D, Smit JH, Smith NL, Soliman EZ, Sotoodehnia N, Staessen JA, Stein PK, Stilp AM, Stolarz-Skrzypek K, Strauch K, Sundström J, Swenne CA, Syvänen AC,Tardif JC, Taylor KD, Teumer A, Thornton TA, Tinker LE, Uitterlinde AG, van Setten J, Voss A, Waldenberger M, Wilhelmsen KC, Willemsen G, Wong Q, Zhang ZM, Zonderman AB, Cusi D, Evans MK, Greiser HK, van der Harst P, Hassan M, Ingelsson E, Järvelin MR, Kääb S, Kähönen M, Kivimaki M, Kooperberg C, Kuh D, Lehtimäki T, Lind L, Nievergelt CM, O’Donnell CJ, Oldehinkel AJ, Penninx B, Reiner AP, Riese H, van Roon AM, Rioux JD, Rotter JI, Sofer T, Stricker BH, Tiemeier H, Vrijkotte TGM, Asselbergs FW, Brundel BJJM, Heckbert SR, Whitsel EA, den Hoed M, Snieder H, de Geus EJC. (2017) Genetic loci associated with heart rate variability and their effects on cardiac disease risk. (2017) Nat Commun. 8:15805. Erratum in: Nat Commun. 8:16140.
  • Duncan LE, Ratanatharathorn A, Aiello AE, Almli LM, Amstadter AB, Ashley-Koch  AE, Baker DG, Beckham JC, Bierut LJ, Bisson J, Bradley B, Chen CY, Dalvie S, Farrer LA, Galea S, Garrett ME, Gelernter JE, Guffanti G, Hauser MA, Johnson EO, Kessler RC, Kimbrel NA, King A, Koen N, Kranzler HR, Logue MW, Maihofer AX, Martin AR, Miller MW, Morey RA, Nugent NR, Rice JP, Ripke S, Roberts AL, Saccone NL, Smoller JW, Stein DJ, Stein MB, Sumner JA, Uddin M, Ursano RJ, Wildman DE, Yehuda R, Zhao H, Daly MJ, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC. (2017) Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability. Mol Psychiatry. Apr 25. doi:10.1038/mp.2017.77. [Epub ahead of print]