3350 La Jolla Village Drive
San Diego, CA 92161
Dr. Hauger has been a Principal Investigator for the VASDHS Research Service since 1985. While serving as Director of the Bioassay and Biomarkers laboratory for CESAMH, he has developed a research program that is highly skilled in assay development to measure novel neuropeptides or other neuroendocrine factors for which assays are not yet available. Dr. Hauger has considerable experience in investigating stress neuroendocrinology at the cellular and molecular levels to clinical stress disorders. He has collaborated with stress neuroendocrine researchers in CESAMH (Drs. Baker, Risbrough, and Lohr), the San Diego VA Research Service, UCSD, the San Francisco VA PTSD Research Program, the National PTSD Center, the National Institutes of Health, the University of Chicago, the University of California Los Angeles, and the University of Minnesota.
Dr. Hauger also directs a molecular biology research program focusing on the molecular regulation of corticotropin releasing factor (CRF) receptor signaling by GRK and arrestin proteins and its role in stress pathophysiology. Since 1987, Dr. Hauger has directed a neuroendocrinology assay maintaining state-of-the-art RIAs, IRMAs, and ELISAs to measure CRF, HPA axis hormones, gonadotropins, androgens, estradiol and progesterone, TSH, neuropeptide Y, BDNF, cytokines, and other neuropeptides, peptide hormones and steroids. Currently he is adding LC-MS/MS spectrometry assay techniques for greater specificity and sensitivity of detection.
- Minassian A, Maihofer AX, Baker DG, Nievergelt CM, Geyer MA, Risbrough VB; Marine Resiliency Study Team. (2015). Association of Predeployment Heart Rate Variability With Risk of Postdeployment Posttraumatic Stress Disorder in Active-Duty Marines. JAMA Psychiatry. 72(10):979-986.
- Park HJ, Ran Y, Jung JI, Holmes O, Price AR, Smithson L, Ceballos-Diaz C, Han C, Wolfe MS, Daaka Y, Ryabinin AE, Kim SH, Hauger RL, Golde TE, Felsenstein KM. (2015). The stress response neuropeptide CRF increases amyloid-β production by regulating γ-secretase activity. European Molecular Biology Organization Journal. 34(12):1674-1686.
- Inslicht SS, Richards A, Madden E, Rao MN, O’Donovan A, Talbot LS, Rucker E, Metzler TJ, Hauger RL, Neylan TC. (2014). Sex differences in neurosteroid and hormonal responses to metyrapone in posttraumatic stress disorder. Psychopharmacology (Berl). 231(17):3581-3595.
- Agorastos A, Hauger RL, Barkauskas DA, Moeller-Bertram T, Clopton PL, Haji U, Lohr JB, Geracioti TD Jr, Patel PM, Chrousos GP, Baker DG. (2014). Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men. Psychoneuroendocrinology. 44:71-82.
- Franz CE, Lyons MJ, Spoon KM, Hauger RL, Jacobson KC, Lohr JB, McKenzie R, Panizzon MS, Thompson WK, Tsuang MT, Vasilopoulos T, Vuoksimaa E, Xian H, Kremen WS. (2014). Post-traumatic stress symptoms and adult attachment: a 24-year longitudinal study. American Journal of Geriatric Psychiatry. (12):1603-1612.
- Baker DG, Bertram TM, Patel PM, Barkauskas DA, Clopton P, Patel S, Geracioti TD Jr, Haji U, O’Connor DT, Nievergelt CM, Hauger RL. (2013). Characterization of cerebrospinal fluid (CSF) and plasma NPY levels in normal volunteers over a 24-h timeframe. Psychoneuroendocrinology. 38(10):2378-2382.
- Toth M, Gresack JE, Hauger RL, Halberstadt AL, Risbrough VB. (2013). The role of PKC signaling in CRF-induced modulation of startle. Psychopharmacology (Berl). 229(4):579-89.
- Hauger RL, Olivares-Reyes JA, Dautzenberg FM, Lohr JB, Braun S, Oakley RH. (2012). Molecular and cell signaling targets for PTSD pathophysiology and pharmacotherapy. Neuropharmacology. 62(2):705-714.
- Franz CE, O’Brien RC, Hauger RL, Mendoza SP, Panizzon MS, Prom-Wormley E, Eaves LJ, Jacobson K, Lyons MJ, Lupien S, Hellhammer D, Xian H, Kremen WS. (2011). Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: the Vietnam Era twin study of aging. Psychoneuroendocrinology. 36(7):1040-1052.
- Heppner PS, Crawford EF, Haji UA, Afari N, Hauger RL, Dashevsky BA, Horn PS, Nunnink SE, Baker DG. (2009). The association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans. BMC Medicine. 7:1.